PDB entry 6cg1

View 6cg1 on RCSB PDB site
Description: Crystal Structure of KDM4A with Compound 14
Class: oxidoreductase/inhibitor
Keywords: KDM4A, Small Molecule Inhibitor, Demethylase, OXIDOREDUCTASE, OXIDOREDUCTASE-INHIBITOR complex
Deposited on 2018-02-19, released 2018-04-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-02, with a file datestamp of 2018-04-27.
Experiment type: XRAY
Resolution: 2.16 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cg1a_
  • Chain 'B':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cg1b_
  • Chain 'C':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cg1c_
  • Chain 'D':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cg1d_
  • Heterogens: NI, ZN, QC1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6cg1A (A:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

    Sequence, based on observed residues (ATOM records): (download) 
    >6cg1A (A:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6cg1B (B:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

    Sequence, based on observed residues (ATOM records): (download) 
    >6cg1B (B:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6cg1C (C:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

    Sequence, based on observed residues (ATOM records): (download) 
    >6cg1C (C:)
arimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipapi
qqlvtgqsglftqyniqkkamtvrefrkiansdkyctpryfeelerkywknltfnppiyg
advngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwktsfawhtedmd
lysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkky
gipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrkism
dvfvrkfqperyklwkagktvidhtlptpeaaefl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6cg1D (D:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

    Sequence, based on observed residues (ATOM records): (download) 
    >6cg1D (D:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgvntpylyfgmwktsfawht
edmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplm
lkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscr
vkismdvfvrkfqperyklwkagkdntvidhtlptpeaaef