PDB entry 6aqg

View 6aqg on RCSB PDB site
Description: Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium ulcerans complexed with L-lysine and Cladosporin
Class: ligase/inhibitor
Keywords: SSGCID, Lysine--tRNA ligase, synthetase, cladosporin, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, LIGASE-INHIBITOR complex
Deposited on 2017-08-19, released 2017-08-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-08-30, with a file datestamp of 2017-08-25.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine--tRNA ligase
    Species: Mycobacterium ulcerans (strain Agy99) [TaxId:362242]
    Gene: lysS, MUL_4181
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6aqga1, d6aqga2
  • Chain 'B':
    Compound: Lysine--tRNA ligase
    Species: Mycobacterium ulcerans (strain Agy99) [TaxId:362242]
    Gene: lysS, MUL_4181
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6aqgb1, d6aqgb2
  • Chain 'C':
    Compound: Lysine--tRNA ligase
    Species: Mycobacterium ulcerans (strain Agy99) [TaxId:362242]
    Gene: lysS, MUL_4181
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6aqgc1, d6aqgc2
  • Chain 'D':
    Compound: Lysine--tRNA ligase
    Species: Mycobacterium ulcerans (strain Agy99) [TaxId:362242]
    Gene: lysS, MUL_4181
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6aqgd1, d6aqgd2
  • Heterogens: LYS, KRS, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6aqgA (A:)
mahhhhhhmssaesnipeqfrirrdkrarllaegydpypvaierthtlaeiratyadlpt
dsatedivgvagrvvfarntgklcfatlqdgdgtqlqamisldevgresldrwkadvdig
dvvyvhgtvissrrgelsvladswrmaakalrplpvahkemseesrvrqryvdlivrpqa
revarqriaviravrnalerrgflevetpmlqtlaggaaarpfvthsnaldidlylriap
elflkrcivggfdrvfelnrvfrnegsdsthspefsmletyqtygtyddsalitreliqe
vadeaigtrqlsmpdgsvydidgewatmemysslsealgeqitpettvarlrdiasgldv
eidnsvfghgklveelwehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvr
gvelatgyselndpvvqrdrfadqaraaaagddeamqldedfltaleygmppctgtgmgi
drllmcltglsiretvlfpivrphsn

    Sequence, based on observed residues (ATOM records): (download) 
    >6aqgA (A:)
peqfrirrdkrarllaegydpypvaierthtlaeiratyadlptdsatedivgvagrvvf
arntgklcfatlqdgdgtqlqamisldevgresldrwkadvdigdvvyvhgtvissrrge
lsvladswrmaakalrplpvahkemseesrvrqryvdlivrpqarevarqriaviravrn
alerrgflevetpmlqtlaggaaarpfvthsnaldidlylriapelflkrcivggfdrvf
elnrvfrnegsdsthspefsmletyqtygtyddsalitreliqevadeaigtrqlsmpdg
svydidgewatmemysslsealgeqitpettvarlrdiasgldveidnsvfghgklveel
wehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvrgvelatgyselndpvv
qrdrfadqaraaaagddeamqldedfltaleygmppctgtgmgidrllmcltglsiretv
lfpivrp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6aqgB (B:)
mahhhhhhmssaesnipeqfrirrdkrarllaegydpypvaierthtlaeiratyadlpt
dsatedivgvagrvvfarntgklcfatlqdgdgtqlqamisldevgresldrwkadvdig
dvvyvhgtvissrrgelsvladswrmaakalrplpvahkemseesrvrqryvdlivrpqa
revarqriaviravrnalerrgflevetpmlqtlaggaaarpfvthsnaldidlylriap
elflkrcivggfdrvfelnrvfrnegsdsthspefsmletyqtygtyddsalitreliqe
vadeaigtrqlsmpdgsvydidgewatmemysslsealgeqitpettvarlrdiasgldv
eidnsvfghgklveelwehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvr
gvelatgyselndpvvqrdrfadqaraaaagddeamqldedfltaleygmppctgtgmgi
drllmcltglsiretvlfpivrphsn

    Sequence, based on observed residues (ATOM records): (download) 
    >6aqgB (B:)
peqfrirrdkrarllaegydpypvaierthtlaeiratyadlptdsatedivgvagrvvf
arntgklcfatlqdgdgtqlqamisldevgresldrwkadvdigdvvyvhgtvissrrge
lsvladswrmaakalrplpvahkemseesrvrqryvdlivrpqarevarqriaviravrn
alerrgflevetpmlqtlaggaaarpfvthsnaldidlylriapelflkrcivggfdrvf
elnrvfrnegsdsthspefsmletyqtygtyddsalitreliqevadeaigtrqlsmpdg
svydidgewatmemysslsealgeqitpettvarlrdiasgldveidnsvfghgklveel
wehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvrgvelatgyselndpvv
qrdrfadqaraaaagddeamqldedfltaleygmppctgtgmgidrllmcltglsiretv
lfpivrp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6aqgC (C:)
mahhhhhhmssaesnipeqfrirrdkrarllaegydpypvaierthtlaeiratyadlpt
dsatedivgvagrvvfarntgklcfatlqdgdgtqlqamisldevgresldrwkadvdig
dvvyvhgtvissrrgelsvladswrmaakalrplpvahkemseesrvrqryvdlivrpqa
revarqriaviravrnalerrgflevetpmlqtlaggaaarpfvthsnaldidlylriap
elflkrcivggfdrvfelnrvfrnegsdsthspefsmletyqtygtyddsalitreliqe
vadeaigtrqlsmpdgsvydidgewatmemysslsealgeqitpettvarlrdiasgldv
eidnsvfghgklveelwehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvr
gvelatgyselndpvvqrdrfadqaraaaagddeamqldedfltaleygmppctgtgmgi
drllmcltglsiretvlfpivrphsn

    Sequence, based on observed residues (ATOM records): (download) 
    >6aqgC (C:)
nipeqfrirrdkrarllaegydpypvaierthtlaeiratyadlptdsatedivgvagrv
vfarntgklcfatlqdgdgtqlqamisldevgresldrwkadvdigdvvyvhgtvissrr
gelsvladswrmaakalrplpvahkemseesrvrqryvdlivrpqarevarqriavirav
rnalerrgflevetpmlqtlaggaaarpfvthsnaldidlylriapelflkrcivggfdr
vfelnrvfrnegsdsthspefsmletyqtygtyddsalitreliqevadeaigtrqlsmp
dgsvydidgewatmemysslsealgeqitpettvarlrdiasgldveidnsvfghgklve
elwehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvrgvelatgyselndp
vvqrdrfadqaraaaagddeamqldedfltaleygmppctgtgmgidrllmcltglsire
tvlfpivrph

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6aqgD (D:)
mahhhhhhmssaesnipeqfrirrdkrarllaegydpypvaierthtlaeiratyadlpt
dsatedivgvagrvvfarntgklcfatlqdgdgtqlqamisldevgresldrwkadvdig
dvvyvhgtvissrrgelsvladswrmaakalrplpvahkemseesrvrqryvdlivrpqa
revarqriaviravrnalerrgflevetpmlqtlaggaaarpfvthsnaldidlylriap
elflkrcivggfdrvfelnrvfrnegsdsthspefsmletyqtygtyddsalitreliqe
vadeaigtrqlsmpdgsvydidgewatmemysslsealgeqitpettvarlrdiasgldv
eidnsvfghgklveelwehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvr
gvelatgyselndpvvqrdrfadqaraaaagddeamqldedfltaleygmppctgtgmgi
drllmcltglsiretvlfpivrphsn

    Sequence, based on observed residues (ATOM records): (download) 
    >6aqgD (D:)
nipeqfrirrdkrarllaegydpypvaierthtlaeiratyadlptdsatedivgvagrv
vfarntgklcfatlqdgdgtqlqamisldevgresldrwkadvdigdvvyvhgtvissrr
gelsvladswrmaakalrplpvemseesrvrqryvdlivrpqarevarqriaviravrna
lerrgflevetpmlqtlaggaaarpfvthsnaldidlylriapelflkrcivggfdrvfe
lnrvfrnegsdsthspefsmletyqtygtyddsalitreliqevadeaigtrqlsmpdgs
vydidgewatmemysslsealgeqitpettvarlrdiasgldveidnsvfghgklveelw
ehavgnkltaptfvkdfpvettpltrqhrsipgvtekwdlyvrgvelatgyselndpvvq
rdrfadqaraaaagddeamqldedfltaleygmppctgtgmgidrllmcltglsiretvl
fpivrph