PDB entry 5us1

View 5us1 on RCSB PDB site
Description: Crystal structure of aminoglycoside acetyltransferase AAC(2')-Ia in complex with N2'-acetylgentamicin C1A and coenzyme A
Class: transferase
Keywords: GNAT, GCN5-N-acetyltransferase, acetyltransferase, aminoglycoside, gentamicin, coenzyme A, acetylcoenzyme A antibiotic resistance, structural genomics, Center for Structural Genomics of Infectious Diseases, CSGID, National Institute of Allergy and Infectious Diseases, NIAID, TRANSFERASE
Deposited on 2017-02-13, released 2017-03-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q52424 (11-188)
      • expression tag (0-10)
    Domains in SCOPe 2.07: d5us1a1, d5us1a2
  • Chain 'B':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5us1b_
  • Chain 'C':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q52424 (11-188)
      • expression tag (4-10)
    Domains in SCOPe 2.07: d5us1c1, d5us1c2
  • Chain 'D':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5us1d_
  • Chain 'E':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q52424 (11-188)
      • expression tag (5-10)
    Domains in SCOPe 2.07: d5us1e1, d5us1e2
  • Chain 'F':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5us1f_
  • Chain 'G':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5us1g_
  • Chain 'H':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5us1h_
  • Chain 'I':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5us1i_
  • Chain 'J':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q52424 (11-188)
      • expression tag (5-10)
    Domains in SCOPe 2.07: d5us1j1, d5us1j2
  • Chain 'K':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q52424 (11-188)
      • expression tag (5-10)
    Domains in SCOPe 2.07: d5us1k1, d5us1k2
  • Chain 'L':
    Compound: Aminoglycoside 2'-N-acetyltransferase
    Species: PROVIDENCIA STUARTII [TaxId:588]
    Gene: aac
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5us1l_
  • Heterogens: 8MM, TAR, ACO, GOL, COA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5us1A (A:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5us1B (B:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1B (B:)
mgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqklvghva
iiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddgq
klyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5us1C (C:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1C (C:)
rgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqq
klvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgll
sasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfr
ggdqw

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5us1D (D:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1D (D:)
gieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqklvghvai
iqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddgqk
lyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5us1E (E:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1E (E:)
gshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqk
lvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlglls
asddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrg
gdqw

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5us1F (F:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1F (F:)
ieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqklvghvaii
qrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddgqkl
yhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5us1G (G:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1G (G:)
gieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqklvghvai
iqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddgqk
lyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5us1H (H:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1H (H:)
mgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqklvghva
iiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddgq
klyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >5us1I (I:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1I (I:)
mgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqklvghva
iiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddgq
klyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >5us1J (J:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1J (J:)
gshmgsmgieyrslhtsqltlsekealydlliegfeddfahtlggmhvmafdqqklvghv
aiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddg
qklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >5us1K (K:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1K (K:)
gshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqk
lvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlglls
asddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrg
gdqw

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5us1L (L:)
glvprgshmgsmgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvma
fdqqklvghvaiiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyq
lgllsasddgqklyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftasly
cdfrggdqw

    Sequence, based on observed residues (ATOM records): (download) 
    >5us1L (L:)
mgieyrslhtsqltlsekealydlliegfegdfshddfahtlggmhvmafdqqklvghva
iiqrhmaldntpisvgyveamvveqsyrrqgigrqlmlqtnkiiascyqlgllsasddgq
klyhsvgwqiwkgklfelkqgsyirsieeeggvmgwkadgevdftaslycdfrggdqw