PDB entry 5u12

View 5u12 on RCSB PDB site
Description: E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-azanyl-8-[(2-fluorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one
Class: transferase
Keywords: E. coli, DHPS, complex, pterin site, TRANSFERASE
Deposited on 2016-11-27, released 2017-12-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-12-06, with a file datestamp of 2017-12-01.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydropteroate synthase
    Species: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [TaxId:199310]
    Gene: folP, c3933
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AC14 (2-283)
      • expression tag (1)
    Domains in SCOPe 2.06: d5u12a1, d5u12a2
  • Chain 'B':
    Compound: dihydropteroate synthase
    Species: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [TaxId:199310]
    Gene: folP, c3933
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AC14 (2-283)
      • expression tag (1)
    Domains in SCOPe 2.06: d5u12b1, d5u12b2
  • Heterogens: 5RU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5u12A (A:)
gsmklfaqgtsldlshphvmgilnvtpdsfsdggthnslidavkhanlminagatiidvg
gestrpgaaevsveeelqrvipvveaiaqrfevwisvdtskpeviresakvgahiindir
slsepgaleaaaetglpvclmhmqgnpktmqeapkyddvfaevnryfieqiarceqagia
kekllldpgfgfgknlshnysllarlaefhhfnlpllvgmsrksmigqllnvgpserlsg
slacaviaamqgahiirvhdvketveamrvveatlsakenkrye

    Sequence, based on observed residues (ATOM records): (download) 
    >5u12A (A:)
smklfaqgtsldlshphvmgilnvtnslidavkhanlminagatiidvggestrpgaaev
sveeelqrvipvveaiaqrfevwisvdtskpeviresakvgahiindirslsepgaleaa
aetglpvclmhmqpkyddvfaevnryfieqiarceqagiakekllldpgfgfgknlshny
sllarlaefhhfnlpllvgmsrksmigqllnvgpserlsgslacaviaamqgahiirvhd
vketveamrvveatlsakenkrye

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5u12B (B:)
gsmklfaqgtsldlshphvmgilnvtpdsfsdggthnslidavkhanlminagatiidvg
gestrpgaaevsveeelqrvipvveaiaqrfevwisvdtskpeviresakvgahiindir
slsepgaleaaaetglpvclmhmqgnpktmqeapkyddvfaevnryfieqiarceqagia
kekllldpgfgfgknlshnysllarlaefhhfnlpllvgmsrksmigqllnvgpserlsg
slacaviaamqgahiirvhdvketveamrvveatlsakenkrye

    Sequence, based on observed residues (ATOM records): (download) 
    >5u12B (B:)
smklfaqgtsldlshphvmgilnvtnslidavkhanlminagatiidvggestrpgaaev
sveeelqrvipvveaiaqrfevwisvdtskpeviresakvgahiindirslsepgaleaa
aetglpvclmhmqgnpktmqeapkyddvfaevnryfieqiarceqagiakekllldpgfg
fgknlshnysllarlaefhhfnlpllvgmsrksmigqllnvgpserlsgslacaviaamq
gahiirvhdvketveamrvveatlsakenkrye