PDB entry 5nhy

View 5nhy on RCSB PDB site
Description: BAY-707 in complex with MTH1
Class: hydrolase
Keywords: nudix, nucleotide hydrolase, inhibitor, oncology, hydrolase
Deposited on 2017-03-22, released 2017-07-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-30, with a file datestamp of 2017-08-25.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nhya_
  • Chain 'B':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nhyb_
  • Heterogens: 8XT, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nhyA (A:)
gshmgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqees
gltvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmw
pddsywfplllqkkkfhgyfkfqgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >5nhyA (A:)
asrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvd
alhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsy
wfplllqkkkfhgyfkfqgqdtildytlrevdtv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5nhyB (B:)
gshmgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqees
gltvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmw
pddsywfplllqkkkfhgyfkfqgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >5nhyB (B:)
asrlytlvlvlqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvdal
hkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsywf
plllqkkkfhgyfkfqgqdtildytlrevdtv