PDB entry 5l9r

View 5l9r on RCSB PDB site
Description: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)
Class: oxidoreductase
Keywords: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, DNA-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
Deposited on 2016-06-10, released 2016-08-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-29, with a file datestamp of 2017-11-24.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Egl nine homolog 1
  Species: Homo sapiens [TaxId:9606]
  Gene: EGLN1, C1orf12, PNAS-118, PNAS-137
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9GZT9
    • engineered mutation (26)
    • engineered mutation (223)
  Domains in SCOPe 2.08: d5l9ra_
• Heterogens: MN, OGA, PG4, SO4, GOL, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >5l9rA (A:)
  gshmaspngqtkplpalklaleyivpamnkhgicvvddflgketgqqigdevralhdtgk
  ftdgqlvsqksdsskdirgdkitwiegkepgcetigllmssmddlirhcngklgsyking
  rtkamvacypgngtgyvrhvdnpngdgrcvtciyylnkdwdakvsggilrifpegkaqfa
  diepkfdrllffwsdrrnphevqpayatryaitvwyfdaderaaakvkyltgekgvrvel
  nkpsdsvgkdvf
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >5l9rA (A:)
  tkplpalklaleyivpamnkhgicvvddflgketgqqigdevralhdtgkftdgqlvsqk
  sdsskdirgdkitwiegkepgcetigllmssmddlirhcngklgsykingrtkamvacyp
  gngtgyvrhvdnpngdgrcvtciyylnkdwdakvsggilrifpegkaqfadiepkfdrll
  ffwsdrrnphevqpayatryaitvwyfdaderaaakvkyl