PDB entry 5kny

View 5kny on RCSB PDB site
Description: Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with (3-((3R,4R)-3-(Guanin-9-yl)-4-((S)-2-hydroxy-2-phosphonoethoxy)pyrrolidin-1-yl)-3-oxopropyl)phosphonic acid
Class: transferase/inhibitor
Keywords: Phosphoribosyltransferase, Inhibitor, Complex, pyrrolidne nucleoside phosphonate, TRANSFERASE-INHIBITOR complex
Deposited on 2016-06-28, released 2017-09-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.91 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: hpt, hprT, Rv3624c, MTCY15C10.28
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5knya_
  • Chain 'B':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: hpt, hprT, Rv3624c, MTCY15C10.28
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5knyb_
  • Chain 'C':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: hpt, hprT, Rv3624c, MTCY15C10.28
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5knyc_
  • Chain 'D':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: hpt, hprT, Rv3624c, MTCY15C10.28
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5knyd_
  • Heterogens: YPG, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5knyA (A:)
hhhhhhhvtqsssaitpgqtaelypgdiksvlltaeqiqariaelgeqigndyrelsatt
gqdlllitvlkgavlfvtdlaraipvptqfefmavssygsstsssgvvrilkdldrdihg
rdvlivedvvdsgltlswlsrnltsrnprslrvctllrkpdavhanveiayvgfdipndf
vvgygldyderyrdlsyigtldprvyq

    Sequence, based on observed residues (ATOM records): (download) 
    >5knyA (A:)
elypgdiksvlltaeqiqariaelgeqigndyrgqdlllitvlkgavlfvtdlaraipvp
tqfefmavssygsssgvvrilkdldrdihgrdvlivedvvdsgltlswlsrnltsrnprs
lrvctllrkpdavhanveiayvgfdipndfvvgygldyderyrdlsyigtldprvy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5knyB (B:)
hhhhhhhvtqsssaitpgqtaelypgdiksvlltaeqiqariaelgeqigndyrelsatt
gqdlllitvlkgavlfvtdlaraipvptqfefmavssygsstsssgvvrilkdldrdihg
rdvlivedvvdsgltlswlsrnltsrnprslrvctllrkpdavhanveiayvgfdipndf
vvgygldyderyrdlsyigtldprvyq

    Sequence, based on observed residues (ATOM records): (download) 
    >5knyB (B:)
aelypgdiksvlltaeqiqariaelgeqigndyrelsattgqdlllitvlkgavlfvtdl
araipvptqfefmavssygsstsssgvvrilkdldrdihgrdvlivedvvdsgltlswls
rnltsrnprslrvctllrkpdavhanveiayvgfdipndfvvgygldyderyrdlsyigt
ldprvyq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5knyC (C:)
hhhhhhhvtqsssaitpgqtaelypgdiksvlltaeqiqariaelgeqigndyrelsatt
gqdlllitvlkgavlfvtdlaraipvptqfefmavssygsstsssgvvrilkdldrdihg
rdvlivedvvdsgltlswlsrnltsrnprslrvctllrkpdavhanveiayvgfdipndf
vvgygldyderyrdlsyigtldprvyq

    Sequence, based on observed residues (ATOM records): (download) 
    >5knyC (C:)
lypgdiksvlltaeqiqariaelgeqigndyrelsattgqdlllitvlkgavlfvtdlar
aipvptqfefmavssygsstsssgvvrilkdldrdihgrdvlivedvvdsgltlswlsrn
ltsrnprslrvctllrkpdavhanveiayvgfdipndfvvgygldyderyrdlsyigtld
prv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5knyD (D:)
hhhhhhhvtqsssaitpgqtaelypgdiksvlltaeqiqariaelgeqigndyrelsatt
gqdlllitvlkgavlfvtdlaraipvptqfefmavssygsstsssgvvrilkdldrdihg
rdvlivedvvdsgltlswlsrnltsrnprslrvctllrkpdavhanveiayvgfdipndf
vvgygldyderyrdlsyigtldprvyq

    Sequence, based on observed residues (ATOM records): (download) 
    >5knyD (D:)
lypgdiksvlltaeqiqariaelgeqigndyrelsattgqdlllitvlkgavlfvtdlar
aipvptqfefmavssygsstsssgvvrilkdldrdihgrdvlivedvvdsgltlswlsrn
ltsrnprslrvctllrkpdavhanveiayvgfdipndfvvgygldyderyrdlsyigtld
prv