PDB entry 5ixy
View 5ixy on RCSB PDB site
Description: Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one
Class: oxireductase/oxireductase inhibitor
Keywords: oxidoreductase tetramer, OXIREDUCTASE-OXIREDUCTASE INHIBITOR complex
Deposited on
2016-03-23, released
2016-09-14
The last revision prior to the SCOPe 2.06 freeze date was dated
2016-09-14, with a file datestamp of
2016-09-09.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: L-lactate dehydrogenase A chain
Species: Homo sapiens [TaxId:9606]
Gene: LDHA, PIG19
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5ixya1, d5ixya2 - Chain 'B':
Compound: L-lactate dehydrogenase A chain
Species: Homo sapiens [TaxId:9606]
Gene: LDHA, PIG19
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5ixyb1, d5ixyb2 - Chain 'C':
Compound: L-lactate dehydrogenase A chain
Species: Homo sapiens [TaxId:9606]
Gene: LDHA, PIG19
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5ixyc1, d5ixyc2 - Chain 'D':
Compound: L-lactate dehydrogenase A chain
Species: Homo sapiens [TaxId:9606]
Gene: LDHA, PIG19
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d5ixyd1, d5ixyd2 - Heterogens: NAD, SO4, GN2
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>5ixyA (A:)
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarqqegesrlnlvqrnvnifkfii
pnvvkyspnckllivsnpvdiltyvawkisgfpknrvigsgcnldsarfrylmgerlgvh
plschgwvlgehgdssvpvwsgmnvagvslktlhpdlgtdkdkeqwkevhkqvvesayev
iklkgytswaiglsvadlaesimknlrrvhpvstmikglygikddvflsvpcilgqngis
dlvkvtltseeearlkksadtlwgiqkelqf
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>5ixyB (B:)
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarqqegesrlnlvqrnvnifkfii
pnvvkyspnckllivsnpvdiltyvawkisgfpknrvigsgcnldsarfrylmgerlgvh
plschgwvlgehgdssvpvwsgmnvagvslktlhpdlgtdkdkeqwkevhkqvvesayev
iklkgytswaiglsvadlaesimknlrrvhpvstmikglygikddvflsvpcilgqngis
dlvkvtltseeearlkksadtlwgiqkelqf
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>5ixyC (C:)
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarqqegesrlnlvqrnvnifkfii
pnvvkyspnckllivsnpvdiltyvawkisgfpknrvigsgcnldsarfrylmgerlgvh
plschgwvlgehgdssvpvwsgmnvagvslktlhpdlgtdkdkeqwkevhkqvvesayev
iklkgytswaiglsvadlaesimknlrrvhpvstmikglygikddvflsvpcilgqngis
dlvkvtltseeearlkksadtlwgiqkelqf
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5ixyD (D:)
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarqqegesrlnlvqrnvnifkfii
pnvvkyspnckllivsnpvdiltyvawkisgfpknrvigsgcnldsarfrylmgerlgvh
plschgwvlgehgdssvpvwsgmnvagvslktlhpdlgtdkdkeqwkevhkqvvesayev
iklkgytswaiglsvadlaesimknlrrvhpvstmikglygikddvflsvpcilgqngis
dlvkvtltseeearlkksadtlwgiqkelqf
Sequence, based on observed residues (ATOM records): (download)
>5ixyD (D:)
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarqqeglnlvqrnvnifkfiipnv
vkyspnckllivsnpvdiltyvawkisgfpknrvigsgcnldsarfrylmgerlgvhpls
chgwvlgehgdssvpvwsgmnvagvslktlhpdlgtdkdkeqwkevhkqvvesayevikl
kgytswaiglsvadlaesimknlrrvhpvstmikglygikddvflsvpcilgqngisdlv
kvtltseeearlkksadtlwgiqkelqf