PDB entry 5ipc

View 5ipc on RCSB PDB site
Description: Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside thiophosphoramidate substrate complex
Class: hydrolase
Keywords: HINT, histidine triad, HIT, HYDROLASE
Deposited on 2016-03-09, released 2017-03-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: N/A
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-128)
      • engineered mutation (114)
    Domains in SCOPe 2.08: d5ipca_
  • Chain 'B':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-128)
      • engineered mutation (114)
    Domains in SCOPe 2.08: d5ipcb_
  • Heterogens: 6CE, EDO, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ipcA (A:)
snamadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipk
khisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvnlhvlg
grqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ipcA (A:)
rpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaeddde
sllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvnlhvlggrqmhwppg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ipcB (B:)
snamadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipk
khisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvnlhvlg
grqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ipcB (B:)
gdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaedddesll
ghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvnlhvlggrqmhwppg