PDB entry 5hzn

View 5hzn on RCSB PDB site
Description: Structure of NVP-AEW541 in complex with IGF-1R kinase
Class: transferase
Keywords: Inhibitor, Kinase, transferase
Deposited on 2016-02-02, released 2016-04-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-12-21, with a file datestamp of 2016-12-16.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hzna_
  • Chain 'B':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hznb_
  • Chain 'C':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hznc_
  • Chain 'D':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08069 (0-303)
      • engineered mutation (114)
      • engineered mutation (116)
    Domains in SCOPe 2.08: d5hznd_
  • Chain 'E':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hzne_
  • Chain 'F':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hznf_
  • Chain 'G':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5hzng_
  • Chain 'H':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08069 (0-End)
      • engineered mutation (114)
      • engineered mutation (116)
    Domains in SCOPe 2.08: d5hznh_
  • Heterogens: 66A, MES, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hznA (A:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hznA (A:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgg
kgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeggl
ldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hznB (B:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hznB (B:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgg
kgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeggl
ldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hznC (C:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hznC (C:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgg
kgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeggl
ldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5hznD (D:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5hznE (E:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hznE (E:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgg
kgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeggl
ldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5hznF (F:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hznF (F:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgg
kgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeggl
ldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5hznG (G:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hznG (G:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgg
kgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeggl
ldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5hznH (H:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
eenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hznH (H:)
aadvyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmr
erieflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpamannp
vlappslskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiye
tdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvl
rfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyys
een