PDB entry 5hd7

View 5hd7 on RCSB PDB site
Description: Dissecting Therapeutic Resistance to ERK Inhibition Rat Mutant SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide
Class: transferase/transferase inhibitor
Keywords: transferase, serine/threonine-protein kinase, map kinase, transferase-transferase inhibitor complex
Deposited on 2016-01-04, released 2016-02-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-02-24, with a file datestamp of 2016-02-19.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Mapk1, Erk2, Mapk, Prkm1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63086
      • engineered mutation (173)
    Domains in SCOPe 2.06: d5hd7a_
  • Heterogens: 38Z, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hd7A (A:)
ahhhhhhmaaaaaagpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikk
ispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykl
lktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfdlarvad
pdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyld
qlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmlt
fnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfq
pgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >5hd7A (A:)
pemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlr
eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfdlarvadpdhdhtgflteyvat
rwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqe
dlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalah
pyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg