PDB entry 5ehr

View 5ehr on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Phosphatase PTP Inhibitor PTPN11 Allosteric, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2015-10-28, released 2016-06-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-06-29, with a file datestamp of 2016-06-24.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ehra1, d5ehra2, d5ehra3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ehrb1, d5ehrb2, d5ehrb3
  • Heterogens: 5OD, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ehrA (A:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >5ehrA (A:)
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehielkyplncadptserwfhghlsgkeaeklltekgkhgs
flvresgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlvehykknpmvetlg
tvlqlkqplnttrinaaeiesrvrelsklakqgfweefetlqqqeckllysrkegqrqen
knknryknilpfdhtrvvlhdgdpnepvsdyinaniimpefkpkksyiatqgclqntvnd
fwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlre
lklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcs
agigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqh
yietl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ehrB (B:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >5ehrB (B:)
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymeielkyplncadptserwfhghlsgkeaeklltekgkhgsf
lvresshpgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykknpmvetlg
tvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenknk
nryknilpfdhtrvvlhvsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivm
ttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertv
wqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividil
idiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl