PDB entry 5ef8

View 5ef8 on RCSB PDB site
Description: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2015-10-23, released 2016-07-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-07-27, with a file datestamp of 2016-07-22.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hdac6 protein
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ef8a_
  • Chain 'B':
    Compound: Hdac6 protein
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5ef8b_
  • Heterogens: ZN, K, LBH, GOL, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ef8A (A:)
snaggsspitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparla
teeelalchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaq
ailtgqvrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvh
hgngtqhifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmg
dpeymaafhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaa
grvliileggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfw
sslr

    Sequence, based on observed residues (ATOM records): (download) 
    >5ef8A (A:)
pitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparlateeelal
chsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaqailtgqv
rnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvhhgngtqh
ifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmgdpeymaa
fhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaagrvliil
eggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfwsslr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ef8B (B:)
snaggsspitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparla
teeelalchsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaq
ailtgqvrnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvh
hgngtqhifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmg
dpeymaafhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaa
grvliileggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfw
sslr

    Sequence, based on observed residues (ATOM records): (download) 
    >5ef8B (B:)
pitglvydqrmmlhhnmwdshhpelpqrisrifsrheelrllsrchriparlateeelal
chsskhisiikssehmkprdlnrlgdeynsifisnesytcallaagscfnsaqailtgqv
rnavaivrppghhaekdtacgfcffntaaltaryaqsitreslrvlivdwdvhhgngtqh
ifeeddsvlyislhryedgaffpnsedanydkvglgkgrgynvnipwnggkmgdpeymaa
fhhlvmpiarefapelvlvsagfdaargdplggfqvtpegyahlthqlmslaagrvliil
eggynltsisesmsmctsmllgdsppsldhltplktsatvsinnvlrahapfwsslr