PDB entry 5e1s

View 5e1s on RCSB PDB site
Description: The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578
Class: transferase
Keywords: Kinase, INSR, IGF-1R, Inhibitor, transferase
Deposited on 2015-09-30, released 2015-10-14
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-10-14, with a file datestamp of 2015-10-09.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06213 (Start-307)
      • conflict (156)
    Domains in SCOPe 2.05: d5e1sa_
  • Heterogens: 5JA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5e1sA (A:)
gsvfpssvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnes
aslrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpea
ennpgrppptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfgmtr
diyetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsn
eqvlkfvmdggyldqpdncpervtdlmrmcwqfnpkmrptfleivnllkddlhpsfpevs
ffhseenk

    Sequence, based on observed residues (ATOM records): (download) 
    >5e1sA (A:)
vyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnesaslreri
eflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaennpgrp
pptlqemiqmaaeiadgmaylnakkfvhrnlaarncmvahdftvkigdfgmlpvrwmape
slkdgvfttssdmwsfgvvlweitslaeqpyqglsneqvlkfvmdggyldqpdncpervt
dlmrmcwqfnpkmrptfleivnllkddlhpsfpevsffhseenk