PDB entry 5d11

View 5d11 on RCSB PDB site
Description: Kinase domain of cSrc in complex with RL235
Class: transferase
Keywords: kinase inhibitor, drug resistance, transferase
Deposited on 2015-08-03, released 2015-09-09
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-09-09, with a file datestamp of 2015-09-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.05: d5d11a_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.05: d5d11b_
  • Heterogens: GOL, 56G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5d11A (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >5d11A (A:)
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmseaqvmkklrheklv
qlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyv
hrdlraanilvgenlvckvadfglfpikwtapeaalygrftiksdvwsfgilltelttkg
rvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledy
ftstepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5d11B (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >5d11B (B:)
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlflqeaqvmkklrheklvql
yavvseepiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhr
dlraanilvgenlvckvadfglarlfpikwtapeaalygrftiksdvwsfgilltelttk
grvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafled
yftstepqyqpgenl