PDB entry 4zh1

View 4zh1 on RCSB PDB site
Description: Complement factor H in complex with the GM1 glycan
Class: immune system
Keywords: lectin, ganglioside, innate immunity, glycans, immune system
Deposited on 2015-04-24, released 2016-01-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-04-13, with a file datestamp of 2016-04-08.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Complement C3
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (9-End)
      • expression tag (8)
      • conflict (23)
    Domains in SCOPe 2.07: d4zh1a1, d4zh1a2
  • Chain 'B':
    Compound: Complement C3
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024
      • conflict (23)
    Domains in SCOPe 2.07: d4zh1b_
  • Chain 'C':
    Compound: Complement C3
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024
      • conflict (23)
    Domains in SCOPe 2.07: d4zh1c_
  • Chain 'D':
    Compound: complement factor h
    Species: Homo sapiens [TaxId:9606]
    Gene: CFH, HF, HF1, HF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08603 (4-128)
      • expression tag (3)
  • Chain 'E':
    Compound: complement factor h
    Species: Homo sapiens [TaxId:9606]
    Gene: CFH, HF, HF1, HF2
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: complement factor h
    Species: Homo sapiens [TaxId:9606]
    Gene: CFH, HF, HF1, HF2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GOL, GAL, SIA, BGC, NGA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4zh1A (A:)
gplgspefrdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgal
elikkgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkw
lilekqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslp
gsitkagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkq
lynveatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkda
pdhqelnldvslqlpsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4zh1A (A:)
rdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkgyt
qqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekqkp
dgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitkagd
fleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynveats
yallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4zh1B (B:)
gplgspefrdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgal
elikkgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkw
lilekqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslp
gsitkagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkq
lynveatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkda
pdhqelnldvslqlpsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4zh1B (B:)
vtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkgytqqlafrqpss
afaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekqkpdgvfqedapv
ihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitkagdfleanymnlq
rsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynveatsyallallqlk
dfdfvppvvrwlneqrygstqatfmvfqalaqyqkdapdhqelnldvslqlp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4zh1C (C:)
gplgspefrdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgal
elikkgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkw
lilekqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslp
gsitkagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkq
lynveatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkda
pdhqelnldvslqlpsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4zh1C (C:)
aerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelikkgytqq
lafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlilekqkpdg
vfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsitkagdfl
eanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynveatsya
llallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.