PDB entry 4xt2

View 4xt2 on RCSB PDB site
Description: Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with a tetrazole-containing antagonist
Class: transcription
Keywords: transcription factor, Hypoxia Inducible Factor, inhibitor, cancer, TRANSCRIPTION
Deposited on 2015-01-22, released 2015-12-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-12-23, with a file datestamp of 2015-12-18.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endothelial PAS domain-containing protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99814 (5-End)
      • expression tag (0-4)
      • engineered mutation (13)
    Domains in SCOPe 2.06: d4xt2a1, d4xt2a2
  • Chain 'B':
    Compound: Aryl hydrocarbon receptor nuclear translocator
    Species: Homo sapiens [TaxId:9606]
    Gene: ARNT, BHLHE2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27540
      • engineered mutation (12)
    Domains in SCOPe 2.06: d4xt2b_
  • Chain 'C':
    Compound: Endothelial PAS domain-containing protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99814 (5-End)
      • expression tag (2-4)
      • engineered mutation (13)
    Domains in SCOPe 2.06: d4xt2c1, d4xt2c2
  • Chain 'D':
    Compound: Aryl hydrocarbon receptor nuclear translocator
    Species: Homo sapiens [TaxId:9606]
    Gene: ARNT, BHLHE2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27540
      • engineered mutation (12)
    Domains in SCOPe 2.06: d4xt2d_
  • Heterogens: 43L, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xt2A (A:)
gefkgldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtksh
qnlctkgqvvsgqyrmlakhggyvwletqgtviynprnlqpqcimcvnyvlseiekn

    Sequence, based on observed residues (ATOM records): (download) 
    >4xt2A (A:)
gefkgldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtksh
qnlctkgqvvsgqyrmlakhggyvwletqgtviynprnlqpqcimcvnyvlseiek

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4xt2B (B:)
gefkglnvcqptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllr
dsfqqvvklkgqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvknssq
e

    Sequence, based on observed residues (ATOM records): (download) 
    >4xt2B (B:)
cqptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllrdsfqqvvk
lkgqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvknss

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4xt2C (C:)
gefkgldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtksh
qnlctkgqvvsgqyrmlakhggyvwletqgtviynprnlqpqcimcvnyvlseiekn

    Sequence, based on observed residues (ATOM records): (download) 
    >4xt2C (C:)
fkgldsktflsehsmdmkftycddriteligyhpeellgrsayefyhaldsenmtkshqn
lctkgqvvsgqyrmlakhggyvwletqgtviynprnlqpqcimcvnyvlseiek

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4xt2D (D:)
gefkglnvcqptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllr
dsfqqvvklkgqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvknssq
e

    Sequence, based on observed residues (ATOM records): (download) 
    >4xt2D (D:)
ptrfisrhniegiftfvdhrcvatvgyqpqellgknivefchpedqqllrdsfqqvvklk
gqvlsvmfrfrsknqewlwmrtssftfqnpysdeieyiictntnvkn