PDB entry 4wdi

View 4wdi on RCSB PDB site
Description: Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Class: immune system
Keywords: Immunoglobulin, H-2Kd, Type 1 Diabetes, Immune System
Deposited on 2014-09-08, released 2015-06-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-10-07, with a file datestamp of 2015-10-02.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • PDB 4WDI (0-276)
    Domains in SCOPe 2.07: d4wdia1, d4wdia2, d4wdia3
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d4wdib1, d4wdib2
  • Chain 'C':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • PDB 4WDI (0-276)
    Domains in SCOPe 2.07: d4wdid1, d4wdid2, d4wdid3
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d4wdie1, d4wdie2
  • Chain 'F':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EDO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wdiA (A:)
mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wdiB (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wdiD (D:)
mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4wdiE (E:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'F':
    No sequence available.