PDB entry 4v3u

View 4v3u on RCSB PDB site
Description: Structure of human nNOS R354A G357D mutant heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl-3-(pyridin-3-yl) propan-1-amine
Class: oxidoreductase
Keywords: oxidoreductase, nitric oxide synthase
Deposited on 2014-10-20, released 2014-12-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-12-24, with a file datestamp of 2014-12-19.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.1912
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nitric oxide synthase, brain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29475 (0-419)
      • engineered mutation (52)
      • engineered mutation (55)
    Domains in SCOPe 2.05: d4v3ua_
  • Chain 'B':
    Compound: Nitric oxide synthase, brain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29475 (0-419)
      • engineered mutation (52)
      • engineered mutation (55)
    Domains in SCOPe 2.05: d4v3ub_
  • Chain 'C':
    Compound: Nitric oxide synthase, brain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29475 (0-419)
      • engineered mutation (52)
      • engineered mutation (55)
    Domains in SCOPe 2.05: d4v3uc_
  • Chain 'D':
    Compound: Nitric oxide synthase, brain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29475 (0-419)
      • engineered mutation (52)
      • engineered mutation (55)
    Domains in SCOPe 2.05: d4v3ud_
  • Heterogens: HEM, H4B, EG8, GOL, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4v3uA (A:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpsqharrpedvatkdqlfp
lakefidqyyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcv
griqwsklqvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwn
sqliryagykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqi
ppelvlevpirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvr
dycdnsrynileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsate
sfikhmeneyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4v3uB (B:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpsqharrpedvatkdqlfp
lakefidqyyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcv
griqwsklqvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwn
sqliryagykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqi
ppelvlevpirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvr
dycdnsrynileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsate
sfikhmeneyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw

    Sequence, based on observed residues (ATOM records): (download) 
    >4v3uB (B:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpvatkdqlfplakefidqy
yssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcvgriqwsklq
vfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwnsqliryagy
kqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqippelvlevp
irhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvrdycdnsryn
ileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsatesfikhmene
yrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4v3uC (C:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpsqharrpedvatkdqlfp
lakefidqyyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcv
griqwsklqvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwn
sqliryagykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqi
ppelvlevpirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvr
dycdnsrynileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsate
sfikhmeneyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4v3uD (D:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpsqharrpedvatkdqlfp
lakefidqyyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcv
griqwsklqvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwn
sqliryagykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqi
ppelvlevpirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvr
dycdnsrynileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsate
sfikhmeneyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw

    Sequence, based on observed residues (ATOM records): (download) 
    >4v3uD (D:)
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpvatkdqlfplakefidqy
yssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcvgriqwsklq
vfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwnsqliryagy
kqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqippelvlevp
irhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvrdycdnsryn
ileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsatesfikhmene
yrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw