PDB entry 4uy1

View 4uy1 on RCSB PDB site
Description: Novel pyrazole series of group X Secretory Phospholipase A2 (sPLA2-X) inhibitors
Class: hydrolase
Keywords: hydrolase, fragment based lead generation, virtual screening, drug discovery
Deposited on 2014-08-28, released 2014-10-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: group 10 secretory phospholipase a2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uy1a_
  • Chain 'B':
    Compound: group 10 secretory phospholipase a2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uy1b_
  • Heterogens: CA, 1PE, DMS, TJM, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4uy1A (A:)
gilelagtvgcvgprtpiaymkygcfcglgghgqprdaidwcchghdccytraeeagcsp
kteryswqcvnqsvlcgpaenkcqellckcdqeianclaqteynlkylfypqflcepdsp
kcdqgilelag

    Sequence, based on observed residues (ATOM records): (download) 
    >4uy1A (A:)
gilelagtvgcvgprtpiaymkygcfcglgghgqprdaidwcchghdccytraeeagcsp
kteryswqcvnqsvlcgpaenkcqellckcdqeianclaqteynlkylfypqflcepdsp
kc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4uy1B (B:)
gilelagtvgcvgprtpiaymkygcfcglgghgqprdaidwcchghdccytraeeagcsp
kteryswqcvnqsvlcgpaenkcqellckcdqeianclaqteynlkylfypqflcepdsp
kcdqgilelag

    Sequence, based on observed residues (ATOM records): (download) 
    >4uy1B (B:)
gilelagtvgcvgprtpiaymkygcfcglgghgqprdaidwcchghdccytraeeagcsp
kteryswqcvnqsvlcgpaenkcqellckcdqeianclaqteynlkylfypqflcepdsp
kcd