PDB entry 4u3t

View 4u3t on RCSB PDB site
Description: Crystal structure of the transpeptidase domain of Neisseria gonorrhoeae penicillin-binding protein 2 derived from the penicillin-resistant strain 6140
Class: hydrolase
Keywords: penicillin-binding protein, transpeptidase domain, peptidoglycan synthesis, antibiotic resistance
Deposited on 2014-07-22, released 2014-12-03
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-12-17, with a file datestamp of 2014-12-12.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.195
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Penicillin-binding protein 2
    Species: Neisseria gonorrhoeae FA6140 [TaxId:528353]
    Gene: penA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08149 (5-329)
      • expression tag (4)
      • conflict (51)
      • insertion (100)
      • engineered mutation (259)
      • engineered mutation (265)
      • engineered mutation (271)
      • engineered mutation (306)
    Domains in SCOPe 2.06: d4u3ta1, d4u3ta2
  • Chain 'B':
    Compound: Penicillin-binding protein 2
    Species: Neisseria gonorrhoeae FA6140 [TaxId:528353]
    Gene: penA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08149 (5-End)
      • expression tag (4)
      • conflict (51)
      • insertion (100)
      • engineered mutation (271)
      • engineered mutation (306)
    Domains in SCOPe 2.06: d4u3tb1, d4u3tb2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4u3tA (A:)
gsggalsldqriqtlayeelnkaveyhqakagtvvvldartgeilalantpgrnravtdm
iepgsaikpfviakaldagktdlnerlntqpykigpspvrddthvypsldvrgimqkssn
vgtsklsarfgaeemydfyhelgigvrmhsgfpgetagllrnwrrwrpieqatmsfgygl
qlsllqlaraytalthdgvllplsfekqavapqgkrifkestarevrnlmvsvtepggtg
tagavdgfdvgaktgtarklvngryvdnkhvgtfigfapaknprvivavtideptahgyy
ggvvagspfkkimggslnilgisptkplta

    Sequence, based on observed residues (ATOM records): (download) 
    >4u3tA (A:)
alsldqriqtlayeelnkaveyhqakagtvvvldartgeilalantpgrnravtdmiepg
saikpfviakaldagktdlnerlntqpykigpspvrddthvypsldvrgimqkssnvgts
klsarfgaeemydfyhelgigvrmhsgfpgetagllrnwrrwrpieqatmsfgyglqlsl
lqlaraytalthdgvllplsfekqavapqgkrifkestarevrnlmvsvtepggtgtaga
vdgfdvgaktgtarklvngryvdnkhvgtfigfapaknprvivavtideptahgvvagsp
fkkimggslnilgisptkplta

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4u3tB (B:)
gsggalsldqriqtlayeelnkaveyhqakagtvvvldartgeilalantpgrnravtdm
iepgsaikpfviakaldagktdlnerlntqpykigpspvrddthvypsldvrgimqkssn
vgtsklsarfgaeemydfyhelgigvrmhsgfpgetagllrnwrrwrpieqatmsfgygl
qlsllqlaraytalthdgvllplsfekqavapqgkrifkestarevrnlmvsvtepggtg
tagavdgfdvgaktgtarklvngryvdnkhvgtfigfapaknprvivavtideptahgyy
ggvvagspfkkimggslnilgisptkplta

    Sequence, based on observed residues (ATOM records): (download) 
    >4u3tB (B:)
alsldqriqtlayeelnkaveyhqakagtvvvldartgeilalantpgrnravtdmiepg
saikpfviakaldagktdlnerlntqpykigpspvrddthvypsldvrgimqkssnvgts
klsarfgaeemydfyhelgigvrmhsgfpgetagllrnwrrwrpieqatmsfgyglqlsl
lqlaraytalthdgvllplsfekqavapqgkrifkestarevrnlmvsvtepggtgtaga
vdgfdvgaktgtarknkhvgtfigfapaknprvivavtideptahggvvagspfkkimgg
slnilgisptkplt