PDB entry 4ttv

View 4ttv on RCSB PDB site
Description: Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194
Class: ligase/antibiotic
Keywords: tRNA, synthetase, inhibitor, macrolide, LIGASE-ANTIBIOTIC complex
Deposited on 2014-06-23, released 2015-09-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26639 (12-413)
      • expression tag (11)
    Domains in SCOPe 2.08: d4ttva1, d4ttva2, d4ttva3
  • Chain 'B':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26639 (12-413)
      • expression tag (11)
    Domains in SCOPe 2.08: d4ttvb1, d4ttvb2, d4ttvb3
  • Chain 'C':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26639 (12-413)
      • expression tag (11)
    Domains in SCOPe 2.08: d4ttvc1, d4ttvc2, d4ttvc3
  • Chain 'D':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26639 (12-413)
      • expression tag (11)
    Domains in SCOPe 2.08: d4ttvd1, d4ttvd2, d4ttvd3
  • Heterogens: BC9, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ttvA (A:)
mgsshhhhhhssdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgf
qevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswre
lplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysv
fgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqik
daigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyg
gkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaq
ynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4ttvA (A:)
sdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifns
rlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvl
hrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlst
rpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcat
iqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprq
vmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgeke
kisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ttvB (B:)
mgsshhhhhhssdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgf
qevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswre
lplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysv
fgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqik
daigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyg
gkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaq
ynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4ttvB (B:)
sdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifns
rlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvl
hrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlst
rpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcat
iqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprq
vmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgeke
kisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ttvC (C:)
mgsshhhhhhssdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgf
qevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswre
lplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysv
fgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqik
daigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyg
gkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaq
ynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4ttvC (C:)
sdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifns
rlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvl
hrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlst
rpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcat
iqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprq
vmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgeke
kisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ttvD (D:)
mgsshhhhhhssdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgf
qevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswre
lplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysv
fgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqik
daigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyg
gkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaq
ynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4ttvD (D:)
sdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifns
rlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvl
hrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlst
rpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcat
iqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprq
vmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgeke
kisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef