PDB entry 4mxx
View 4mxx on RCSB PDB site
Description: Human Src A403T mutant bound to kinase inhibitor bosutinib
Class: transferase/transferase inhibitor
Keywords: Kinase, Phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2013-09-26, released
2013-12-04
The last revision prior to the SCOPe 2.05 freeze date was dated
2014-02-05, with a file datestamp of
2014-01-31.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.213
AEROSPACI score: 0.22
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Homo sapiens [TaxId:9606]
Gene: SRC, SRC1
Database cross-references and differences (RAF-indexed):
- Uniprot P12931 (Start-285)
- engineered mutation (155)
Domains in SCOPe 2.05: d4mxxa_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Homo sapiens [TaxId:9606]
Gene: SRC, SRC1
Database cross-references and differences (RAF-indexed):
- Uniprot P12931 (Start-285)
- engineered mutation (155)
Domains in SCOPe 2.05: d4mxxb_ - Heterogens: DB8, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4mxxA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvtdfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkepeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>4mxxA (A:)
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkk
lrheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdmaaqiasgmay
vermnyvhrdlraanilvgenlvckvtdfglarliefpikwtapeaalygrftiksdvws
fgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerp
tfeylqafledyftstepqyqpgenl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4mxxB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvtdfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkepeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>4mxxB (B:)
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkkl
rheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvtdfglfpikwtapeaalygrftiksdvwsfgillt
elttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerptfeylq
afledyftstepqyqpgenl