PDB entry 4mlp

View 4mlp on RCSB PDB site
Description: Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase
Class: transcription
Keywords: photolyase homology region, transcriptional repressor, PERIOD, FBXL3, CLOCK, nucleus, TRANSCRIPTION
Deposited on 2013-09-06, released 2013-10-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-12-18, with a file datestamp of 2013-12-13.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: 0.18
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cryptochrome-2
    Species: Mus musculus [TaxId:10090]
    Gene: Cry2, Kiaa0658
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mlpa1, d4mlpa2
  • Chain 'B':
    Compound: Cryptochrome-2
    Species: Mus musculus [TaxId:10090]
    Gene: Cry2, Kiaa0658
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mlpb1, d4mlpb2
  • Chain 'C':
    Compound: Cryptochrome-2
    Species: Mus musculus [TaxId:10090]
    Gene: Cry2, Kiaa0658
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mlpc1, d4mlpc2
  • Chain 'D':
    Compound: Cryptochrome-2
    Species: Mus musculus [TaxId:10090]
    Gene: Cry2, Kiaa0658
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mlpd1, d4mlpd2
  • Heterogens: 2CX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mlpA (A:)
maaaavvaatvpaqsmgadgassvhwfrkglrlhdnpallaavrgarcvrcvyildpwfa
asssvginrwrfllqsledldtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeyds
epfgkerdaaimkmakeagvevvtenshtlydldriielngqkppltykrfqalisrmel
pkkpavavssqqmescraeiqenhddtygvpsleelgfpteglgpavwqggetealarld
khlerkawvanyerprmnansllasptglspylrfgclscrlfyyrlwdlykkvkrnstp
plslfgqllwreffytaatnnprfdrmegnpiciqipwdrnpealakwaegktgfpwida
imtqlrqegwihhlarhavacfltrgdlwvswesgvrvfdellldadfsvnagswmwlsc
saffqqffhcycpvgfgrrtdpsgdyirrylpklkgfpsryiyepwnapesvqkaakcii
gvdyprpivnhaetsrlniermkqiyqqlsry

    Sequence, based on observed residues (ATOM records): (download) 
    >4mlpA (A:)
assvhwfrkglrlhdnpallaavrgarcvrcvyildpwfaasssvginrwrfllqsledl
dtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeydsepfgkerdaaimkmakeagv
evvtenshtlydldriielngqkppltykrfqalisrmelpkkpavavssqqmescraei
qenhddtygvpsleelgfpteglgpavwqggetealarldkhlerkawvanyerprmnan
sllasptglspylrfgclscrlfyyrlwdlykkvkrnstpplslfgqllwreffytaatn
nprfdrmegnpiciqipwdrnpealakwaegktgfpwidaimtqlrqegwihhlarhava
cfltrgdlwvswesgvrvfdellldadfsvnagswmwlscsaffqqffhcycpvgfgrrt
dpsgdyirrylpklkgfpsryiyepwnapesvqkaakciigvdyprpivnhaetsrlnie
rmkqiyqqlsry

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mlpB (B:)
maaaavvaatvpaqsmgadgassvhwfrkglrlhdnpallaavrgarcvrcvyildpwfa
asssvginrwrfllqsledldtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeyds
epfgkerdaaimkmakeagvevvtenshtlydldriielngqkppltykrfqalisrmel
pkkpavavssqqmescraeiqenhddtygvpsleelgfpteglgpavwqggetealarld
khlerkawvanyerprmnansllasptglspylrfgclscrlfyyrlwdlykkvkrnstp
plslfgqllwreffytaatnnprfdrmegnpiciqipwdrnpealakwaegktgfpwida
imtqlrqegwihhlarhavacfltrgdlwvswesgvrvfdellldadfsvnagswmwlsc
saffqqffhcycpvgfgrrtdpsgdyirrylpklkgfpsryiyepwnapesvqkaakcii
gvdyprpivnhaetsrlniermkqiyqqlsry

    Sequence, based on observed residues (ATOM records): (download) 
    >4mlpB (B:)
assvhwfrkglrlhdnpallaavrgarcvrcvyildpwfaasssvginrwrfllqsledl
dtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeydsepfgkerdaaimkmakeagv
evvtenshtlydldriielngqkppltykrfqalisrmelpkkpavavssqqmescraei
qenhddtygvpsleelgfpteglgpavwqggetealarldkhlerkawvanyerprmnan
sllasptglspylrfgclscrlfyyrlwdlykkvkrnstpplslfgqllwreffytaatn
nprfdrmegnpiciqipwdrnpealakwaegktgfpwidaimtqlrqegwihhlarhava
cfltrgdlwvswesgvrvfdellldadfsvnagswmwlscsaffqqffhcycpvgfgrrt
dpsgdyirrylpklkgfpsryiyepwnapesvqkaakciigvdyprpivnhaetsrlnie
rmkqiyqqlsry

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4mlpC (C:)
maaaavvaatvpaqsmgadgassvhwfrkglrlhdnpallaavrgarcvrcvyildpwfa
asssvginrwrfllqsledldtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeyds
epfgkerdaaimkmakeagvevvtenshtlydldriielngqkppltykrfqalisrmel
pkkpavavssqqmescraeiqenhddtygvpsleelgfpteglgpavwqggetealarld
khlerkawvanyerprmnansllasptglspylrfgclscrlfyyrlwdlykkvkrnstp
plslfgqllwreffytaatnnprfdrmegnpiciqipwdrnpealakwaegktgfpwida
imtqlrqegwihhlarhavacfltrgdlwvswesgvrvfdellldadfsvnagswmwlsc
saffqqffhcycpvgfgrrtdpsgdyirrylpklkgfpsryiyepwnapesvqkaakcii
gvdyprpivnhaetsrlniermkqiyqqlsry

    Sequence, based on observed residues (ATOM records): (download) 
    >4mlpC (C:)
assvhwfrkglrlhdnpallaavrgarcvrcvyildpwfaasssvginrwrfllqsledl
dtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeydsepfgkerdaaimkmakeagv
evvtenshtlydldriielngqkppltykrfqalisrmelpkkpavavssqqmescraei
qenhddtygvpsleelgfpteglgpavwqggetealarldkhlerkawvanyerprmnan
sllasptglspylrfgclscrlfyyrlwdlykkvkrnstpplslfgqllwreffytaatn
nprfdrmegnpiciqipwdrnpealakwaegktgfpwidaimtqlrqegwihhlarhava
cfltrgdlwvswesgvrvfdellldadfsvnagswmwlscsaffqqffhcycpvgfgrrt
dpsgdyirrylpklkgfpsryiyepwnapesvqkaakciigvdyprpivnhaetsrlnie
rmkqiyqqlsry

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4mlpD (D:)
maaaavvaatvpaqsmgadgassvhwfrkglrlhdnpallaavrgarcvrcvyildpwfa
asssvginrwrfllqsledldtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeyds
epfgkerdaaimkmakeagvevvtenshtlydldriielngqkppltykrfqalisrmel
pkkpavavssqqmescraeiqenhddtygvpsleelgfpteglgpavwqggetealarld
khlerkawvanyerprmnansllasptglspylrfgclscrlfyyrlwdlykkvkrnstp
plslfgqllwreffytaatnnprfdrmegnpiciqipwdrnpealakwaegktgfpwida
imtqlrqegwihhlarhavacfltrgdlwvswesgvrvfdellldadfsvnagswmwlsc
saffqqffhcycpvgfgrrtdpsgdyirrylpklkgfpsryiyepwnapesvqkaakcii
gvdyprpivnhaetsrlniermkqiyqqlsry

    Sequence, based on observed residues (ATOM records): (download) 
    >4mlpD (D:)
assvhwfrkglrlhdnpallaavrgarcvrcvyildpwfaasssvginrwrfllqsledl
dtslrklnsrlfvvrgqpadvfprlfkewgvtrltfeydsepfgkerdaaimkmakeagv
evvtenshtlydldriielngqkppltykrfqalisrmelpkkpavavssqqmescraei
qenhddtygvpsleelgfpteglgpavwqggetealarldkhlerkawvanyerprmnan
sllasptglspylrfgclscrlfyyrlwdlykkvkrnstpplslfgqllwreffytaatn
nprfdrmegnpiciqipwdrnpealakwaegktgfpwidaimtqlrqegwihhlarhava
cfltrgdlwvswesgvrvfdellldadfsvnagswmwlscsaffqqffhcycpvgfgrrt
dpsgdyirrylpklkgfpsryiyepwnapesvqkaakciigvdyprpivnhaetsrlnie
rmkqiyqqlsry