PDB entry 4m5m

View 4m5m on RCSB PDB site
Description: The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Class: transferase/transferase inhibitor
Keywords: FOLATE BIOSYNTHESIS, Diphosphotransferases, PTERIN, ATP binding, Inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-08-08, released 2014-04-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-16, with a file datestamp of 2014-04-11.
Experiment type: XRAY
Resolution: 1.12 Å
R-factor: 0.171
AEROSPACI score: 0.8 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    Species: Escherichia coli [TaxId:83333]
    Gene: folK, b0142, JW0138
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m5ma_
  • Heterogens: DX4, APC, CA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m5mA (A:)
gshmtvayiaigsnlaspleqvnaalkalgdipeshiltvssfyrtpplgpqdqpdylna
avaletslapeellnhtqrielqqgrvrkaerwgprtldldimlfgnevinterltvphy
dmknrgfmlwplfeiapelvfpdgemlrqilhtrafdklnkw

    Sequence, based on observed residues (ATOM records): (download) 
    >4m5mA (A:)
mtvayiaigsnlaspleqvnaalkalgdipeshiltvssfyrtpplgpqdqpdylnaava
letslapeellnhtqrielqqgrvrkaerwgprtldldimlfgnevinterltvphydmk
nrgfmlwplfeiapelvfpdgemlrqilhtrafdklnkw