PDB entry 4lzn

View 4lzn on RCSB PDB site
Description: Crystal structure of human PRS1 D65N mutant
Class: transferase
Keywords: PRS1, PRPP synthesis enzyme, ATP R5P, TRANSFERASE
Deposited on 2013-07-31, released 2015-02-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-03-25, with a file datestamp of 2015-03-20.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribose-phosphate pyrophosphokinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60891
      • engineered mutation (64)
    Domains in SCOPe 2.08: d4lzna1, d4lzna2
  • Chain 'B':
    Compound: Ribose-phosphate pyrophosphokinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60891
      • engineered mutation (64)
    Domains in SCOPe 2.08: d4lznb1, d4lznb2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lznA (A:)
mpnikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgc
geinnnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvag
adhiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvts
iadrlnvdfalihkerkkanevdrmvlvgdvkdrvailvddmadtcgtichaadkllsag
atrvyailthgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeai
rrthngesvsylfshvpllehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4lznA (A:)
nikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgcge
innnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvagad
hiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvtsia
drlnvdfalihkedrmvlvgdvkdrvailvddmadtcgtichaadkllsagatrvyailt
hgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeairrthngesv
sylf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lznB (B:)
mpnikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgc
geinnnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvag
adhiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvts
iadrlnvdfalihkerkkanevdrmvlvgdvkdrvailvddmadtcgtichaadkllsag
atrvyailthgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeai
rrthngesvsylfshvpllehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4lznB (B:)
nikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgedvyivqsgcge
innnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvagad
hiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvtsia
drlnvdfalihkedrmvlvgdvkdrvailvddmadtcgtichaadkllsagatrvyailt
hgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeairrthngesv
sylfshvp