PDB entry 4lfv

View 4lfv on RCSB PDB site
Description: Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-06-27, released 2014-03-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-08-27, with a file datestamp of 2014-08-22.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.179
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'F':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4lfvf_
  • Heterogens: YS4, PO4, MG, CL, HOH

PDB Chain Sequences:

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4lfvF (F:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafysfylpiaaamymag
idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >4lfvF (F:)
dvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvva
frelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgld
aindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvr
ftekryksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyld
lfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyee
ldlpavflqyeedsyshimalieqyaaplppavflglarkiy