PDB entry 4kqu

View 4kqu on RCSB PDB site
Description: Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
Class: transferase
Keywords: Isoprene biosynthesis, Lipid synthesis, steroid biosynthesis, Transferase, dimethylallyl pyrophosphate, Isoprenoid Pathway, Cholesterol Synthesis, Bisphosphonates
Deposited on 2013-05-15, released 2014-04-30
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-04-30, with a file datestamp of 2014-04-25.
Experiment type: XRAY
Resolution: 2.07 Å
R-factor: 0.178
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14324 (Start-374)
      • engineered mutation (225)
    Domains in SCOPe 2.05: d4kqua_
  • Heterogens: MG, IPE, AHD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kquA (A:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafasfylpiaaamymag
idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >4kquA (A:)
yaqekqdfvqhfsqivrvltehpeigdaiarlkevleynaiggkynrgltvvvafrelve
prkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaindan
lleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekry
ksivkyktafasfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdps
vtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpav
flqyeedsyshimalieqyaaplppavflglarkiykrrk