PDB entry 4k8b

View 4k8b on RCSB PDB site
Description: Crystal structure of HCV NS3/4A protease complexed with inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: protease, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-04-18, released 2014-03-26
The last revision prior to the SCOPe 2.03 freeze date was dated 2014-03-26, with a file datestamp of 2014-03-21.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.204
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NS3 protease
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4k8ba_
  • Chain 'B':
    Compound: NS3 protease
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4k8bb_
  • Chain 'C':
    Compound: Nonstructural protein
    Species: Hepatitis C virus [TaxId:11103]
    Gene: NS3-NS4
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Nonstructural protein
    Species: Hepatitis C virus [TaxId:11103]
    Gene: NS3-NS4
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, 1RR, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4k8bA (A:)
apitaysqqtrgllgciitsltgrdknqvegevqvvstatqsflatcvngvcwtvyhgag
sktlagpkgpitqmytnvdqdlvgwqappgarsltpctcgssdlylvtrhadvipvrrrg
dsrgsllsprpvsylkgssggpllcpsghavgifraavctrgvakavdfvpvesmettmr
s

    Sequence, based on observed residues (ATOM records): (download) 
    >4k8bA (A:)
itaysqqtrgllgciitsltgrdknqvegevqvvstatqsflatcvngvcwtvyhgagsk
tlagpkgpitqmytnvdqdlvgwqappgarsltpctcgssdlylvtrhadvipvrrrgds
rgsllsprpvsylkgssggpllcpsghavgifraavctrgvakavdfvpvesmettm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4k8bB (B:)
apitaysqqtrgllgciitsltgrdknqvegevqvvstatqsflatcvngvcwtvyhgag
sktlagpkgpitqmytnvdqdlvgwqappgarsltpctcgssdlylvtrhadvipvrrrg
dsrgsllsprpvsylkgssggpllcpsghavgifraavctrgvakavdfvpvesmettmr
s

    Sequence, based on observed residues (ATOM records): (download) 
    >4k8bB (B:)
itaysqqtrgllgciitsltgrdknqvegevqvvstatqsflatcvngvcwtvyhgagsk
tlagpkgpitqmytnvdqdlvgwqappgarsltpctcgssdlylvtrhadvipvrrrgds
rgsllsprpvsylkgssggpllcpsghavgifraavctrgvakavdfvpvesmettm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.