PDB entry 4jtk

View 4jtk on RCSB PDB site
Description: Crystal structure of R117Q mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Class: transferase
Keywords: manno-octulosonate, synthase, lipopolysaccharide, kdop, kdo8 kdops, kdo8ps, tim barrel, transferase, lipopolysaccharide biosynthesis
Deposited on 2013-03-23, released 2013-06-26
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-12-18, with a file datestamp of 2013-12-13.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.178
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (116)
    Domains in SCOPe 2.05: d4jtka_
  • Chain 'B':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (116)
    Domains in SCOPe 2.05: d4jtkb_
  • Chain 'C':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (116)
    Domains in SCOPe 2.05: d4jtkc_
  • Chain 'D':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (116)
    Domains in SCOPe 2.05: d4jtkd_
  • Heterogens: CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4jtkA (A:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
    pklakcdgpsalplhlledflirikalddliksqpiltie
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jtkA (A:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqtrgrraqaldlalagmatrlaglflelhlledflirik
    alddliksqpil
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4jtkB (B:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
    pklakcdgpsalplhlledflirikalddliksqpiltie
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jtkB (B:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqtrrraqaldlalagmatrlaglfleshlledflirika
    lddliksqpilti
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4jtkC (C:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
    pklakcdgpsalplhlledflirikalddliksqpiltie
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jtkC (C:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqrraqaldlalagmatrlaglfleshpalplhlledfli
    rikalddliksqpilt
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4jtkD (D:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
    pklakcdgpsalplhlledflirikalddliksqpiltie
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jtkD (D:)
    mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
    ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlpaflaqqtd
    lvvamaktgnvvnikkpqflspsqmknivekfheagngklilcergssfgydnlvvdmlg
    fgvmkqtcgnlpvifdvthslqtrrraqaldlalagmatrlaglfleshpalplhlledf
    lirikalddliksqpil