PDB entry 4j0a

View 4j0a on RCSB PDB site
Description: Crystal structure of hcv ns5b polymerase in complex with 2-{[(4-METHYLPHENYL)SULFONYL]AMINO}-4-PHENOXYBENZOIC ACID
Class: transferase/transferase inhibitor
Keywords: RNA-DIRECTED RNA POLYMERASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-01-30, released 2013-04-17
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-05-01, with a file datestamp of 2013-04-26.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.256
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Genome polyprotein
    Species: Hepatitis C virus [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4j0aa_
  • Chain 'B':
    Compound: Genome polyprotein
    Species: Hepatitis C virus [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4j0ab_
  • Heterogens: 1JL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4j0aA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrarprhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4j0aA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqprkparlivfpdlgvrvcekmalydvvstlpq
avmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccd
lapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacr
aaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinr
vasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasq
ldlsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4j0aB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrarprhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4j0aB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvgrkparlivfpdlgvrvcekmalydvvstlpqa
vmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdl
apearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacra
aklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrv
asclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasql
dlsgwfvagysggdiyhs