PDB entry 4i8a

View 4i8a on RCSB PDB site
Description: Alanine-glyoxylate aminotransferase variant S187F
Class: transferase
Keywords: aminotransferase, primary hyperoxaluria type 1, peroxisome, TRANSFERASE
Deposited on 2012-12-03, released 2013-05-01
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-08-07, with a file datestamp of 2013-08-02.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.253
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine-pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549 (Start-393)
      • engineered mutation (188)
    Domains in SCOPe 2.05: d4i8aa_
  • Chain 'B':
    Compound: Serine-pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549
      • engineered mutation (188)
    Domains in SCOPe 2.05: d4i8ab_
  • Chain 'C':
    Compound: Serine-pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549
      • engineered mutation (188)
    Domains in SCOPe 2.05: d4i8ac_
  • Chain 'D':
    Compound: Serine-pyruvate aminotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AGXT, AGT1, SPAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21549
      • engineered mutation (188)
    Domains in SCOPe 2.05: d4i8ad_
  • Heterogens: GOL

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4i8aA (A:)
gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
lllvdsvaflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
lrigllgcnatrenvdrvtealraalqhcpkkkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8aA (A:)
llvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegiq
yvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvhp
mtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvdsv
aflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldik
wlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqal
glqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigllg
cnatrenvdrvtealraalqhcpkkkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4i8aB (B:)
gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
lllvdsvaflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
lrigllgcnatrenvdrvtealraalqhcpkkkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8aB (B:)
kllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegi
qyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvh
pmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvds
vaflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldi
kwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqa
lglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigll
gcnatrenvdrvtealraalqhcpkk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4i8aC (C:)
gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
lllvdsvaflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
lrigllgcnatrenvdrvtealraalqhcpkkkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8aC (C:)
llvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegiq
yvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvhp
mtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvdsv
aflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldik
wlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqal
glqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigllg
cnatrenvdrvtealraalqhcpkk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4i8aD (D:)
gamashkllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimd
eikegiqyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdiger
igarvhpmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykc
lllvdsvaflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpf
sfyldikwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaayl
hgrlqalglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkv
lrigllgcnatrenvdrvtealraalqhcpkkkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8aD (D:)
kllvtppkallkplsipnqlllgpgpsnlpprimaagglqmigsmskdmyqimdeikegi
qyvfqtrnpltlvisgsghcaleaalvnvlepgdsflvgangiwgqravdigerigarvh
pmtkdpgghytlqeveeglaqhkpvllflthgesstgvlqpldgfgelchrykclllvds
vaflggtplymdrqgidilysgsqkalnappgtslisfsdkakkkmysrktkpfsfyldi
kwlanfwgcddqprmyhhtipvislyslreslaliaeqglenswrqhreaaaylhgrlqa
lglqlfvkdpalrlptvttvavpagydwrdivsyvidhfdieimgglgpstgkvlrigll
gcnatrenvdrvtealraalqhcpkk