PDB entry 4gd7

View 4gd7 on RCSB PDB site
Description: Wild-Type Human Thymidylate Synthase with bound Purpurogallin
Class: transferase/transferase inhibitor
Keywords: Methyltransferase, Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-07-31, released 2013-07-31
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 2.29 Å
R-factor: 0.24
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: tys, ts, ok/sw-cl.29
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4gd7a_
  • Heterogens: EDO, TIY, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gd7A (A:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >4gd7A (A:)
phgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqg
vdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsg
dmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfp
klrilrkvekiddfkaedfqiegynphptikme