PDB entry 4do3

View 4do3 on RCSB PDB site
Description: Structure of FAAH with a non-steroidal anti-inflammatory drug
Class: hydrolase/hydrolase inhibitor
Keywords: AMIDASE, HYDROLASE, ANANDAMIDE, NSAID, DRUG, COX, INHIBITOR, INFLAMMATION, PAIN, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-02-09, released 2013-01-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-01-23, with a file datestamp of 2013-01-18.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.166
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Faah, Faah1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4do3a_
  • Chain 'B':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Faah, Faah1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4do3b_
  • Heterogens: CL, OHO, 0LA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4do3A (A:)
mgsshhhhhhssglvprgshmtgrqkargaatrarqkqrasletmdkavqrfrlqnpdld
sealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqlsqapr
qgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqs
mlsfdcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfpsafcg
icglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftldptvp
plpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpnnipy
alevlsagglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplfprla
aflnsmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgratga
isytvlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglpvavq
cvalpwqeelclrfmreveqlmtpqhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4do3A (A:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmlsfdcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlsagglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnsmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgaisytvlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
tpq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4do3B (B:)
mgsshhhhhhssglvprgshmtgrqkargaatrarqkqrasletmdkavqrfrlqnpdld
sealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqlsqapr
qgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqs
mlsfdcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfpsafcg
icglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftldptvp
plpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpnnipy
alevlsagglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplfprla
aflnsmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgratga
isytvlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglpvavq
cvalpwqeelclrfmreveqlmtpqhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4do3B (B:)
tgrqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgel
speavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghd
stlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmlsfdcsnplfgqtmnpwkss
kspggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvy
gqtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyye
tdnytmpspamrralietkqrleaaghtlipflpnnipyalevlsagglfsdggrsflqn
fkgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnsmrprsaeklwklqhei
emyrqsviaqwkamnldvlltpmlgpaldlntpgratgaisytvlyncldfpagvvpvtt
vtaeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveql
mtpq