PDB entry 3w2t

View 3w2t on RCSB PDB site
Description: Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin
Class: hydrolase/hydrolase inhibitor
Keywords: ALPHA/BETA, BETA-PROPELLER, HYDROLASE, AMINOPEPTIDASE, SERINE PROTEASE, SECRETED, SIGNAL-ANCHOR, TRANSMEMBRANE, DIABETES, GLYCOPROTEIN, CELL MEMBRANE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-12-04, released 2013-05-15
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-05-15, with a file datestamp of 2013-05-10.
Experiment type: XRAY
Resolution: 2.36 Å
R-factor: 0.183
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3w2ta1, d3w2ta2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3w2tb1, d3w2tb2
  • Heterogens: LF7, GOL, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3w2tA (A:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3w2tA (A:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3w2tB (B:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3w2tB (B:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp