PDB entry 3v0m

View 3v0m on RCSB PDB site
Description: Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (5GW) and H-antigen acceptor
Class: transferase/transferase inhibitor
Keywords: GTA, ABO, CISAB MUTANT, AA(GLY)B, ROSSMANN FOLD, "closed" CONFORMATION, GLYCOSYLTRANSFERASE, GLYCOPROTEIN, BLOOD GROUP ANTIGEN, UDP-GalNAc, METAL-BINDING, MANGANESE, Glycosylation, TRANSMEMBRANE, GOLGI APPARATUS, SECRETED, SIGNAL-ANCHOR, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-12-08, released 2013-01-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: 0.165
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histo-blood group ABO system transferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AB0, ABO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16442 (7-End)
      • expression tag (1-6)
      • engineered mutation (209)
      • engineered mutation (211)
    Domains in SCOPe 2.05: d3v0ma_
  • Chain 'B':
    Compound: Histo-blood group ABO system transferase
    Species: Homo sapiens [TaxId:9606]
    Gene: AB0, ABO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16442 (7-End)
      • expression tag (1-6)
      • engineered mutation (209)
      • engineered mutation (211)
    Domains in SCOPe 2.05: d3v0mb_
  • Heterogens: MN, 5GW, BHE, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3v0mA (A:)
maigefmvslprmvypqpkvltpcrkdvlvvtpwlapivwegtfnidilneqfrlqntti
gltvfaikkyvaflklfletaekhfmvghrvhyyvftdqpaavprvtlgtgrqlsvlevr
aykrwqdvsmrrmemisdfcerrflsevdylvcvdvdmefrdhvgveiltplfgtlhpgf
ygssreaftyerrpqsqayipkdegdfyyggaffggsvqevqrltrachqammvdqangi
eavwhdeshlnkyllrhkptkvlspeylwdqqllgwpavlrklrftavpknhqavrnp

    Sequence, based on observed residues (ATOM records): (download) 
    >3v0mA (A:)
aigefmvslprmvypqpkvltpcrkdvlvvtpwlapivwegtfnidilneqfrlqnttig
ltvfaikkyvaflklfletaekhfmvghrvhyyvftdqpaavprvtlgtgrqlsvlevra
ykrwqdvsmrrmemisdfcerrflsevdylvcvdvdmefrdhvgveiltplfgtlhpgfy
gssreaftyerrpqsqayipkdegdfyyggaffggsvqevqrltrachqammvdqangie
avwhdeshlnkyllrhkptkvlspeylwdqqllgwpavlrklrftavpk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3v0mB (B:)
maigefmvslprmvypqpkvltpcrkdvlvvtpwlapivwegtfnidilneqfrlqntti
gltvfaikkyvaflklfletaekhfmvghrvhyyvftdqpaavprvtlgtgrqlsvlevr
aykrwqdvsmrrmemisdfcerrflsevdylvcvdvdmefrdhvgveiltplfgtlhpgf
ygssreaftyerrpqsqayipkdegdfyyggaffggsvqevqrltrachqammvdqangi
eavwhdeshlnkyllrhkptkvlspeylwdqqllgwpavlrklrftavpknhqavrnp

    Sequence, based on observed residues (ATOM records): (download) 
    >3v0mB (B:)
aigefmvslprmvypqpkvltpcrkdvlvvtpwlapivwegtfnidilneqfrlqnttig
ltvfaikkyvaflklfletaekhfmvghrvhyyvftdqpaavprvtlgtgrqlsvlevra
ykrwqdvsmrrmemisdfrflsevdylvcvdvdmefrdhvgveiltplfgtlhpgfygss
reaftyerrpqsqayipkdegdfyyggaffggsvqevqrltrachqammvdqangieavw
hdeshlnkyllrhkptkvlspeylwdqqllgwpavlrklrftavpk