PDB entry 3sfh

View 3sfh on RCSB PDB site
Description: Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: deacetylase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-06-13, released 2011-07-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-08-03, with a file datestamp of 2011-07-29.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.179
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3sfha_
  • Heterogens: K, ZN, ACT, 1DI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sfhA (A:)
smeepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkp
kvasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggat
itaaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldl
hhgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdek
yyqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatl
ilggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnep
hriqqilnyikgnlkhvv

    Sequence, based on observed residues (ATOM records): (download) 
    >3sfhA (A:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqgifdyaaaiggatitaaqclidgmckvainwsggwhhakkdeasgfcyl
ndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslhkfspgffpgtgdvs
dvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkavvlqlgadtiagdpmc
sfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyltgvilgktlsseipdhe
fftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv