PDB entry 3rvh

View 3rvh on RCSB PDB site
Description: Crystal Structure of JMJD2A Complexed with Inhibitor
Class: Oxidoreductase/Oxidoreductase Inhibitor
Keywords: Oxidoreductase, jmjC Domain, Chromatin Regulator, Dioxygenase, Transcription, Iron, 2-oxoglutarate, alpha-ketoglutarate, Demethylation, Nucleus, Oxidoreductase-Oxidoreductase Inhibitor complex
Deposited on 2011-05-06, released 2012-05-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3rvha_
  • Chain 'B':
    Compound: lysine-specific demethylase 4a
    Species: Homo sapiens [TaxId:9606]
    Gene: JHDM3A, JMJD2, JMJD2A, KDM4A, KIAA0677
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3rvhb_
  • Heterogens: NI, ZN, HQ2, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3rvhA (A:)
mhhhhhhssgvdlgtenlyfqsmasesetlnpsarimtfyptmeefrnfsryiayiesqg
ahraglakvvppkewkprasyddiddlvipapiqqlvtgqsglftqyniqkkamtvrefr
kiansdkyctprysefeelerkywknltfnppiygadvngtlyekhvdewnigrlrtild
lvekesgitiegvntpylyfgmwktsfawhtedmdlysinylhfgepkswysvppehgkr
lerlakgffpgsaqsceaflrhkmtlisplmlkkygipfdkvtqeagefmitfpygyhag
fnhgfncaestnfatrrwieygkqavlcscrkdmvkismdvfvrkfqperyklwkagkdn
tvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >3rvhA (A:)
sesetlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddi
ddlvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkyw
knltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwk
tsfawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkm
tlisplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkq
avlcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaef

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3rvhB (B:)
mhhhhhhssgvdlgtenlyfqsmasesetlnpsarimtfyptmeefrnfsryiayiesqg
ahraglakvvppkewkprasyddiddlvipapiqqlvtgqsglftqyniqkkamtvrefr
kiansdkyctprysefeelerkywknltfnppiygadvngtlyekhvdewnigrlrtild
lvekesgitiegvntpylyfgmwktsfawhtedmdlysinylhfgepkswysvppehgkr
lerlakgffpgsaqsceaflrhkmtlisplmlkkygipfdkvtqeagefmitfpygyhag
fnhgfncaestnfatrrwieygkqavlcscrkdmvkismdvfvrkfqperyklwkagkdn
tvidhtlptpeaaeflkesel

    Sequence, based on observed residues (ATOM records): (download) 
    >3rvhB (B:)
setlnpsarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddidd
lvipapiqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywkn
ltfnppiygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwkts
fawhtedmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtl
isplmlkkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqav
lcscrkdmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl