SCOPe 2.08: Structural Classification of Proteins

PDB entry 3r1b

View 3r1b on RCSB PDB site
Description: Open crystal structure of cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: cytochrome P450 2B4, monooxygenase, membrane protein, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2011-03-09, released 2011-05-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Cytochrome P450 2B4
Species: Oryctolagus cuniculus [TaxId:9986]
Gene: CYP2B4
Database cross-references and differences (RAF-indexed):
- Uniprot P00178 (Start-471)
  - engineered mutation (9)
  - conflict (201)
  - engineered mutation (206)
  - expression tag (472)
Domains in SCOPe 2.08: d3r1ba1, d3r1ba2
Chain 'B':
Compound: Cytochrome P450 2B4
Species: Oryctolagus cuniculus [TaxId:9986]
Gene: CYP2B4
Database cross-references and differences (RAF-indexed):
- Uniprot P00178 (Start-471)
  - engineered mutation (9)
  - conflict (201)
  - engineered mutation (206)
  - expression tag (472)
Domains in SCOPe 2.08: d3r1bb1, d3r1bb2
Chain 'C':
Compound: Cytochrome P450 2B4
Species: Oryctolagus cuniculus [TaxId:9986]
Gene: CYP2B4
Database cross-references and differences (RAF-indexed):
- Uniprot P00178 (Start-471)
  - engineered mutation (9)
  - conflict (201)
  - engineered mutation (206)
  - expression tag (472)
Domains in SCOPe 2.08: d3r1bc1, d3r1bc2
Chain 'D':
Compound: Cytochrome P450 2B4
Species: Oryctolagus cuniculus [TaxId:9986]
Gene: CYP2B4
Database cross-references and differences (RAF-indexed):
- Uniprot P00178 (Start-471)
  - engineered mutation (9)
  - conflict (201)
  - engineered mutation (206)
Domains in SCOPe 2.08: d3r1bd_
Heterogens: HEM, TB2, CM5

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3r1bA (A:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

Sequence, based on observed residues (ATOM records): (download)

>3r1bA (A:)
gklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdairea
lvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgkrsveeriq
eearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfs
lissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidv
yllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyphvtervqke
ieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipknte
vfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelf
lffttilqnfsiaspvppedidltpresgvgnvppsyqirflarh

Chain 'B':
Sequence, based on SEQRES records: (download)

>3r1bB (B:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

Sequence, based on observed residues (ATOM records): (download)

>3r1bB (B:)
gklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdairea
lvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgkrsveeriq
eearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfs
lissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidv
yllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyphvtervqke
ieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipknte
vfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelf
lffttilqnfsiaspvppedidltpresgvgnvppsyqirflarh

Chain 'C':
Sequence, based on SEQRES records: (download)

>3r1bC (C:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

Sequence, based on observed residues (ATOM records): (download)

>3r1bC (C:)
gklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdairea
lvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgkrsveeriq
eearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfs
lissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidv
yllrmekdhqnliltvlslffagtettsttlrygfllmlkyphvtervqkeieqvigshr
ppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipkntevfpvlssal
hdpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelflffttilqn
fsiaspvppedidltpresgvgnvppsyqirflarh

Chain 'D':
Sequence, based on SEQRES records: (download)

>3r1bD (D:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

Sequence, based on observed residues (ATOM records): (download)

>3r1bD (D:)
gklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdairea
lvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgkrsveeriq
eearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfs
lissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidv
yllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyphvtervqke
ieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipknte
vfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelf
lffttilqnfsiaspvppedidltpresgvgnvppsyqirflar