PDB entry 3r01
View 3r01 on RCSB PDB site
Description: The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
Class: transferase/transferase inhibitor
Keywords: Kinase, Pim1, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2011-03-07, released
2011-05-11
The last revision prior to the SCOPe 2.01 freeze date was dated
2011-05-11, with a file datestamp of
2011-05-06.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.219
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene serine/threonine-protein kinase Pim-1
Species: Homo sapiens [TaxId:9606]
Gene: PIM1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3r01a_ - Heterogens: IMD, UNE, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3r01A (A:)
mkekeplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvp
mevvllkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsf
fwqvleavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvy
sppewiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhli
rwclalrpsdrptfeeiqnhpwmqdvllpqetaeihlhslspgpskaaalehhhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3r01A (A:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlhs