PDB entry 3p4f

View 3p4f on RCSB PDB site
Description: Structural and biochemical insights into MLL1 core complex assembly and regulation.
Class: transcription
Keywords: beta-propeller, scaffold, MLL1, RbBP5, TRANSCRIPTION
Deposited on 2010-10-06, released 2010-12-08
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-04-20, with a file datestamp of 2011-04-15.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.197
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3p4fa_
  • Chain 'B':
    Compound: Retinoblastoma-binding protein 5
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15291 (Start-10)
      • engineered mutation (10)
  • Chain 'C':
    Compound: Histone-lysine N-methyltransferase MLL
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03164 (Start-9)
      • engineered mutation (2)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3p4fA (A:)
gamgsatqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydg
kfektisghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnf
npqsnlivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcri
wdtasgqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghkn
ekycifanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniia
saalendktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >3p4fA (A:)
vkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfektisghklgi
sdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnlivsgsfd
esvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasgqclktli
dddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfsvtg
gkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendktiklw
ksdc

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.