PDB entry 3nu6

View 3nu6 on RCSB PDB site
Description: Crystal Structure of HIV-1 Protease Mutant I54M with Antiviral Drug Amprenavir
Class: hydrolase/hydrolase inhibitor
Keywords: enzyme inhibition, aspartic protease, HIV/AIDS, Amprenavir, conformational change, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2010-07-06, released 2010-08-25
The last revision prior to the SCOPe 2.02 freeze date was dated 2010-11-24, with a file datestamp of 2010-11-19.
Experiment type: XRAY
Resolution: 1.16 Å
R-factor: 0.154
AEROSPACI score: 0.86 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: GAG, POL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-98)
    • engineered mutation (6)
    • engineered mutation (32)
    • engineered mutation (53)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (94)
  Domains in SCOPe 2.02: d3nu6a_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: GAG, POL
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-98)
    • engineered mutation (6)
    • engineered mutation (32)
    • engineered mutation (53)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (94)
  Domains in SCOPe 2.02: d3nu6b_
• Heterogens: CL, NA, ACT, 478, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3nu6A (A:)
  pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfmkvrqyd
  qiiieiaghkaigtvlvgptpvniigrnlltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3nu6B (B:)
  pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfmkvrqyd
  qiiieiaghkaigtvlvgptpvniigrnlltqigatlnf