PDB entry 3mz7

View 3mz7 on RCSB PDB site
Description: Crystal structure of D101L Co2+ HDAC8 complexed with M344
Class: hydrolase
Keywords: hydrolase, metallohydrolase, arginase-like
Deposited on 2010-05-11, released 2010-06-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-03-02, with a file datestamp of 2011-02-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.222
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (100)
      • expression tag (377)
    Domains in SCOPe 2.06: d3mz7a1, d3mz7a2
  • Heterogens: CO, K, B3N, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mz7A (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgylcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3mz7A (A:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqeeyglgylcpategifdyaaaiggatitaaqclidgmckvainwsggwh
hakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslhk
fspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkavvl
qlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyltgvi
lgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvvi