PDB entry 3mxf

View 3mxf on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JQ1
Class: cell cycle
Keywords: Bromodomain-containing protein 4 isoform long, BRD4, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, JQ1, betsoff1, Structural Genomics Consortium, SGC, CELL CYCLE
Deposited on 2010-05-07, released 2010-10-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-03-28, with a file datestamp of 2012-03-23.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.151
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1, Mcap
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (0-126)
    • conflict (1)
  Domains in SCOPe 2.06: d3mxfa_
• Heterogens: JQ1, IOD, EDO, DMS, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3mxfA (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee