PDB entry 3lxs

View 3lxs on RCSB PDB site
Description: Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (WRR483)
Class: hydrolase
Keywords: cysteine protease, covalent inhibitor, vinyl sulfonamide, hydrolase
Deposited on 2010-02-25, released 2010-10-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cruzain
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: cruzipain
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3lxsa_
  • Chain 'C':
    Compound: cruzain
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: cruzipain
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3lxsc_
  • Heterogens: 4MC, EDO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3lxsA (A:)
apaavdwrargavtavkdqgqcgscwafsaignvecqwflaghpltnlseqmlvscdktd
sgcsgglmnnafewivqenngavytedsypyasgegisppcttsghtvgatitghvelpq
deaqiaawlavngpvavavdasswmtytggvmtscvseqldhgvllvgyndsaavpywii
knswttqwgeegyiriakgsnqclvkeeassavvg

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3lxsC (C:)
apaavdwrargavtavkdqgqcgscwafsaignvecqwflaghpltnlseqmlvscdktd
sgcsgglmnnafewivqenngavytedsypyasgegisppcttsghtvgatitghvelpq
deaqiaawlavngpvavavdasswmtytggvmtscvseqldhgvllvgyndsaavpywii
knswttqwgeegyiriakgsnqclvkeeassavvg