PDB entry 3ljz

View 3ljz on RCSB PDB site
Description: Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound
Class: hydrolase/hydrolase inhibitor
Keywords: MMP-13 inhibitor; zinc chelating agent; S1' pocket, Collagen degradation, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Protease, Secreted, Zymogen, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2010-01-26, released 2011-02-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45452 (1-163)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d3ljza1, d3ljza2
  • Chain 'B':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45452 (1-163)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d3ljzb1, d3ljzb2
  • Chain 'C':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45452 (1-163)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d3ljzc1, d3ljzc2
  • Chain 'D':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45452 (1-163)
      • engineered mutation (0)
    Domains in SCOPe 2.08: d3ljzd1, d3ljzd2
  • Heterogens: CA, ZN, SO4, LA3, EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ljzA (A:)
anvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslyg

    Sequence, based on observed residues (ATOM records): (download) 
    >3ljzA (A:)
anvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytythfmlpdddvqgiqslyg

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ljzB (B:)
anvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslyg

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ljzC (C:)
anvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslyg

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ljzD (D:)
anvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslyg