PDB entry 3l9h

View 3l9h on RCSB PDB site
Description: X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the hexahydro-2H-pyrano[3,2-c]quinoline EMD 534085
Class: motor protein
Keywords: mitotic spindle kinesin, EG5, small molecule inhibitor, EMD 534085, Acetylation, ATP-binding, Cell cycle, Cell division, Coiled coil, Microtubule, Mitosis, Motor protein, Nucleotide-binding, Phosphoprotein, Polymorphism
Deposited on 2010-01-05, released 2010-03-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-03-02, with a file datestamp of 2010-02-26.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.234
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kinesin-like protein KIF11
    Species: Homo sapiens [TaxId:9606]
    Gene: EG5, KIF11, KNSL1, TRIP5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3l9ha_
  • Chain 'B':
    Compound: Kinesin-like protein KIF11
    Species: Homo sapiens [TaxId:9606]
    Gene: EG5, KIF11, KNSL1, TRIP5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3l9hb_
  • Heterogens: ADP, EMQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3l9hA (A:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3l9hA (A:)
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgas
tkqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagi
iprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvi
ikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeel
vkigklnlvdlagseninqslltlgrvitalvertphvpyreskltrilqdslggrtrts
iiatispaslnleetlstleyahraknilnk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3l9hB (B:)
masqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladk
ssrktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegers
pneeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvse
rlqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfs
vtihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvit
alvertphvpyreskltrilqdslggrtrtsiiatispaslnleetlstleyahraknil
nkpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3l9hB (B:)
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgas
tkqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagi
iprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvi
ikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeel
vkigklnlvdlagseninqslltlgrvitalvertphvpyreskltrilqdslggrtrts
iiatispaslnleetlstleyahraknilnk