PDB entry 3krr

View 3krr on RCSB PDB site
Description: Crystal Structure of JAK2 complexed with a potent quinoxaline ATP site inhibitor
Class: transferase
Keywords: Small molecule inhibitor, ATP site kinase inhibitor, ATP-binding, Disease mutation, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2009-11-19, released 2010-07-21
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-07-21, with a file datestamp of 2010-07-16.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.169
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.01: d3krra_
  • Heterogens: DQX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3krrA (A:)
gsdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfer
eieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqyt
sqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgesp
ifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfh
liellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3krrA (A:)
sdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfere
ieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqyts
qickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespi
fwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhl
iellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma