PDB entry 3k84

View 3k84 on RCSB PDB site
Description: Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase
Class: hydrolase
Keywords: faah, oxazole, conjugate, covalent modification, Hydrolase, Membrane, Transmembrane, oxadiazole, alpha-ketoheterocycle, monotopic, fatty acid, serine hydrolase, endocannabinoid, reversible inhibitor.
Deposited on 2009-10-13, released 2009-12-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-01-19, with a file datestamp of 2010-01-15.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.168
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Faah, faah-1, Faah1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P97612
      • engineered (185)
      • engineered (187)
      • engineered (370)
      • engineered (428)
      • engineered (484)
      • engineered (488)
    Domains in SCOPe 2.08: d3k84a_
  • Chain 'B':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Faah, faah-1, Faah1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P97612
      • engineered (185)
      • engineered (187)
      • engineered (370)
      • engineered (428)
      • engineered (484)
      • engineered (488)
    Domains in SCOPe 2.08: d3k84b_
  • Heterogens: K84, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k84A (A:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >3k84A (A:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
tpqkqp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3k84B (B:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >3k84B (B:)
tgrqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgel
speavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghd
stlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkss
kspggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvy
gqtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyye
tdnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqn
fkgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqhei
emyrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvtt
vtaeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveql
mtp