SCOPe 2.01: Structural Classification of Proteins

PDB entry 3k3a

View 3k3a on RCSB PDB site
Description: Crystal Structure of B/Perth Neuraminidase D197E mutant in complex with Oseltamivir
Class: hydrolase
Keywords: INFLUENZA, NEURAMINIDASE, MUTATION, RESISTANCE, TAMIFLU, Oseltamivir, GS-4071, 196618-13-0, HYDROLASE, Cell membrane, Glycosidase, Membrane, Transmembrane, Virion
Deposited on 2009-10-02, released 2010-09-01
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-09-15, with a file datestamp of 2010-09-10.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: 0.208
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3aa_
Chain 'B':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ab_
Chain 'C':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ac_
Chain 'D':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ad_
Chain 'E':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ae_
Chain 'F':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3af_
Chain 'G':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ag_
Chain 'H':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ah_
Chain 'I':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ai_
Chain 'J':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3aj_
Chain 'K':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ak_
Chain 'L':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3al_
Chain 'M':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3am_
Chain 'N':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3an_
Chain 'O':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ao_
Chain 'P':
Compound: Neuraminidase
Species: Influenza B virus [TaxId:343983]
Database cross-references and differences (RAF-indexed):
- Uniprot Q3S340 (Start-396)
  - engineered (127)
Domains in SCOPe 2.01: d3k3ap_
Heterogens: NAG, CA, G39, YT3, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3k3aA (A:)
gvtlllpepewtyprlscpgstfqkallisphrfgetkgnsapliirepfiacgpkeckh
falthyaaqpggyyngtrgdrnklrhlisvklgkiptvensifhmaawsgsachdgkewt
yigvdgpennallkikygeaytdtyhsyannilrtqesacnciggncylmitdgsasgis
ecrflkiregriikeifptgrvkhteectcgfasnktiecacrdnsytakrpfvklnvet
dtaeirlmctetyldtprpddgsitgpcesngdkgsggikggfvhqrmaskigrwysrtm
sktkrmgmglyvkydgdpwtdsdalalsgvmvsmeepgwysfgfeikdkkcdvpcigiem
vhdggketwhsaataiyclmgsgqllwdtvtgvdmal